Unit I

Basic principles of Cell injury and Adaptation

Introduction, definitions, Homeostasis, Components and Types of Feedback systems, Causes of cellular injury,Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage),Morphology of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia),Cell swelling, Intra cellular accumulation, Calcification, Enzyme leakage and Cell Death Acidosis &Alkalosis,Electrolyte imbalance

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Basic mechanism involved in the process of inflammation and repair

Introduction, Clinical signs of inflammation, Different types of Inflammation,Mechanism of Inflammation – Alteration in vascular permeability and blood flow, migration of WBC’s,Mediators of inflammation,Basic principles of wound healing in the skin,Pathophysiology of Atherosclerosis

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Unit II

Cardiovascular System

Hypertension, congestive heart failure, ischemic heart disease (angina,myocardial infarction, atherosclerosis and arteriosclerosis)

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Respiratory system

Asthma, Chronic obstructive airways diseases

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Renal system

Acute and chronic renal failure

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Unit III

Haematological Diseases

Iron deficiency, megaloblastic anemia (Vit B12 and folic acid), sickle cell anemia, thalasemia, hereditary acquired anemia, hemophilia

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Endocrine system

Diabetes, thyroid diseases, disorders of sex hormones

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Nervous system

Epilepsy, Parkinson’s disease, stroke, psychiatric disorders: depression, schizophrenia and Alzheimer’s disease.

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Gastrointestinal system

Peptic Ulcer

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Unit IV

                      Inflammatory bowel diseases, jaundice, hepatitis (A,B,C,D,E,F) alcoholic liver disease

Disease of bones and joints

Rheumatoid arthritis, osteoporosis and gout

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Principles of cancer

classification, etiology and pathogenesis of cancer

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Unit V

Infectious diseases

Meningitis,Typhoid, Leprosy, Tuberculosis Urinary tract infections

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Sexually transmitted diseases

AIDS, Syphilis, Gonorrhea

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