Medicinal Chemistry – II Free Notes Download – B. Pharm

Unit I

Antihistaminic agents

Histamine, receptors and their distribution in the humanbody

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H1–antagonists

Diphenhydramine hydrochloride*, Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride*, Phenidamine tartarate, Promethazine hydrochloride*, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium

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H2-antagonists

Cimetidine*, Famotidine, Ranitidin

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Gastric Proton pump inhibitors

Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole

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Anti-neoplastic agents

Alkylating agents

Meclorethamine*, Cyclophosphamide, Melphalan,

                      Chlorambucil, Busulfan, Thiotepa

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Antimetabolites

Mercaptopurine*, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate*, Azathioprine

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Antibiotics

Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin

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Plant products

Etoposide, Vinblastin sulphate, Vincristin sulphate

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Miscellaneous

Cisplatin, Mitotane

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Unit II

Anti-anginal

Vasodilators

Amyl nitrite, Nitroglycerin*, Pentaerythritol tetranitrate, Isosorbide dinitrite*, Dipyridamole

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Calcium channel blockers

Verapamil, Bepridil hydrochloride, Diltiazem hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine

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Diuretics

Carbonic anhydrase inhibitors: Acetazolamide*, Methazolamide, Dichlorphenamide.
Thiazides: Chlorthiazide*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide,
Loop diuretics: Furosemide*, Bumetanide, Ethacrynic acid. Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride. Osmotic Diuretics: Mannitol

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Anti-hypertensive Agents

Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride,* Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride

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Unit III

Anti-arrhythmic Drugs

Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate*, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol

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Anti-hyperlipidemic agents

Clofibrate, Lovastatin, Cholesteramine and Cholestipol

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Coagulant & Anticoagulants

Menadione, Acetomenadione, Warfarin*, Anisindione, clopidogrel

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Drugs used in Congestive Heart Failure

Digoxin, Digitoxin, Nesiritide, Bosentan, Tezosentan.

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Unit IV

Drugs acting on Endocrine system

Nomenclature, Stereochemistry and metabolism of steroids

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Sex hormones

Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol, Oestrione, Diethyl stilbestrol

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Drugs for erectile dysfunction

Sildenafil, Tadalafil

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Oral contraceptives

Mifepristone, Norgestril, Levonorgestrol

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Corticosteroids

Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone

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Thyroid and antithyroid drugs

L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazole

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Unit V

Antidiabetic agents

Insulin and its preparations
Sulfonyl ureas: Tolbutamide*, Chlorpropamide, Glipizide, Glimepiride. Biguanides: Metformin.
Thiazolidinediones: Pioglitazone, Rosiglitazone. Meglitinides: Repaglinide, Nateglinide.
Glucosidase inhibitors: Acrabose, Voglibose

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Local Anesthetics

SAR of Local anesthetics

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Benzoic Acid derivatives

Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine, Piperocaine

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Amino Benzoic acid derivatives

Benzocaine*, Butamben, Procaine*, Butacaine, Propoxycaine, Tetracaine, Benoxinate

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Lidocaine/Anilide derivatives

Lignocaine, Mepivacaine, Prilocaine, Etidocaine

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Miscellaneous

Phenacaine, Diperodon, Dibucaine

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